Retro 2
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $900 | Check With Us |
| 250mg | $1500 | Check With Us |
| 500mg | $2250 | Check With Us |
: Cat #: V2432 CAS #: 1201652-50-7 Purity ≥ 99%
Description: Retro-2 is a plant toxin ricin inhibitor.
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| Molecular Weight (MW) | 320.41 |
|---|---|
| Molecular Formula | C₁₉H₁₆N₂OS |
| CAS No. | 1201652-50-7 |
| Synonyms | Retro2 ;Retro-2 ;Retro 2 ; |
| Protocol | In Vitro | Retro-2 (1 μM; 1-4 hours) induces autophagy in GFP-LC3-expressing HeLa cells and promoted the dramatic cytoplasmic accumulation of large autophagosomes. |
|---|---|---|
| In Vivo | Retro-2 (2-200 mg/kg; i.p; daily; for 21 days) treatment clearly protects from lethal nasal exposure to ricin in mice. 200 mg/kg of Retro-2 fully protects mice against ricin challenge. | |
| Animal model | Female Balb/c mice (Pathogen-free 6-week-old) injected with ricin (2 μg/kg) | |
| Dosages | 2 mg/kg, 10 mg/kg, 20 mg/kg, 200 mg/kg | |
| Administration | Intraperitoneal injection; daily; for 21 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.1210 mL | 15.6050 mL | 31.2100 mL | 62.4200 mL |
| 5mM | 0.6242 mL | 3.1210 mL | 6.2420 mL | 12.4840 mL |
| 10mM | 0.3121 mL | 1.5605 mL | 3.1210 mL | 6.2420 mL |
| 20mM | 0.1561 mL | 0.7803 mL | 1.5605 mL | 3.1210 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.