RepSox (SJN 2511)

This product is for research use only, not for human use. We do not sell to patients.

RepSox (SJN 2511)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
10mg$90In Stock
25mg$140In Stock
50mg$230In Stock
100mg$340In Stock
250mg$540In Stock
email: [email protected]        [email protected]

Cat #: V1373 CAS #: 446859-33-2 Purity ≥ 99%

Description: RepSox (also called E-616452, SJN-2511; E 616452; SJN 2511, and ALK5 Inhibitor II) is a potent, cell permeable, and selective inhibitor of the TGFβR-1/ALK5 (transforming growth factor-beta type I receptor, ALK5) with important biological activity. It inhibits TGFβR-1/ALK5 with an IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation in cell-free assays, respectively. RepSox slows the decay of CD34+ acute myeloid leukemia cells and decreases T cell immunoglobulin mucin-3 expression. RepSox inhibited ALK5 autophosphorylation with IC50 = 6 and 4 nM, respectively, showed potent activities in both binding and cellular assays and exhibited selectivity over p38 mitogen-activated protein kinase.

Top Publications Citing Invivochem Products
Product Catalog 2022
Bulletin Board
Guide to Product Handling
Publications Citing InvivoChem Products
Product Promise
Promise
Molecular Weight (MW)287.32
Molecular FormulaC17H13N5
CAS No.446859-33-2
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

SynonymsE-616452, SJN 2511; E 616452; 446859-33-2; 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine; ALK5 Inhibitor II; ALK5 Inhibitor; SJN 2511; 2-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine; C17H13N5; E616452; RepSox; SJN-2511; SJN-2511; ALK5 Inhibitor II
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.4804 mL17.4022 mL34.8044 mL69.6088 mL
5mM0.6961 mL3.4804 mL6.9609 mL13.9218 mL
10mM0.3480 mL1.7402 mL3.4804 mL6.9609 mL
20mM0.1740 mL0.8701 mL1.7402 mL3.4804 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
×
Volume
 
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
×
 
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.