Ravoxertinib hydrochloride (GDC-0994; RG7842)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$915	To Be Confirmed
500mg	$1380	To Be Confirmed
1g	$2070	To Be Confirmed

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Cat #: V4529 CAS #: 2070009-58-2 Purity ≥ 98%

Description: Ravoxertinib hydrochloride (GDC-0994; RG-7842), the hydrochloride salt of Ravoxertinib, is an orally bioavailable inhibitor of extracellular signal-regulated kinase (ERK1/2) being developed as an anticancer drug.

References: Blake JF, et al. Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Developme

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	477.32
Molecular Formula	C₂₁H₁₉Cl₂FN₆O₂
CAS No.	2070009-58-2
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: > 100 mg/mLr
	Water: N/Ar
	Ethanol: N/A
Solubility In Vivo	2% DMSO+30% PEG 300+5% Tween 80+ddH2O: 30 mg/mL
Synonyms	RG 7842 HCl; GDC0994; GDC-0994; GDC 0994; RG7842; RG-7842; RG 7842

Protocol	In Vitro	Ravoxertinib also inhibits p90RSK with IC50 of 12 nM.
Protocol	In Vivo	In CD-1 mice, a 10 mg/kg oral dose of Ravoxertinib is sufficient to achieve the desired target coverage for at least 8 h.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.0950 mL	10.4752 mL	20.9503 mL	41.9006 mL
5mM	0.4190 mL	2.0950 mL	4.1901 mL	8.3801 mL
10mM	0.2095 mL	1.0475 mL	2.0950 mL	4.1901 mL
20mM	0.1048 mL	0.5238 mL	1.0475 mL	2.0950 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.