Ravoxertinib (GDC-0994; RG-7842)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $925 | Check With Us |
| 500mg | $1460 | Check With Us |
| 1g | $2190 | Check With Us |
: Cat #: V0466 CAS #: 1453848-26-4 Purity ≥ 98%
Description: Ravoxertinib (formerly known as GDC0994; RG7842) is a novel, potent, orally bioavailable inhibitor of extracellular signal-regulated kinase (ERK1/2) with potential antineoplastic activity.
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- Physicochemical and Storage Information
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- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 439.85 |
|---|---|
| Molecular Formula | C21H18ClFN6O2 |
| CAS No. | 1453848-26-4 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 87 mg/mL (197.8 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 87 mg/mL (197.8 mM) | |
| Solubility In Vivo | 2% DMSO+30% PEG 300+5% Tween 80+ddH2O: 30 mg/mL |
| SMILES Code | O=C1C=C(C2=NC(NC3=CC=NN3C)=NC=C2)C=CN1[C@@H](C4=CC=C(Cl)C(F)=C4)CO |
| Synonyms | RG7842; GDC-0994; RG 7842; GDC 0994; GDC0994;RG-7842; |
| Protocol | In Vitro | Ravoxertinib (GDC-0994) also inhibits p90RSK with an IC50 of 12 nM. |
|---|---|---|
| In Vivo | In CD-1 mice, a 10 mg/kg oral dose of Ravoxertinib (GDC-0994) is sufficient to achieve the desired target coverage for at least 8 h. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2735 mL | 11.3675 mL | 22.7350 mL | 45.4700 mL |
| 5mM | 0.4547 mL | 2.2735 mL | 4.5470 mL | 9.0940 mL |
| 10mM | 0.2274 mL | 1.1368 mL | 2.2735 mL | 4.5470 mL |
| 20mM | 0.1137 mL | 0.5684 mL | 1.1368 mL | 2.2735 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.