Rasagiline Mesylate
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 1g | $390 | Check With Us |
| 2g | $590 | Check With Us |
| 5g | $995 | Check With Us |
: Cat #: V0902 CAS #: 161735-79-1 Purity ≥ 98%
Description: Rasagiline mesylate (TVP-101; TV-1030, TVP-1022; Agn-1135; Azilect) is a potent, selective and irreversible MAO-B (monoamine oxidase B) inhibitor with the potential for the treatment of idiopathic PD/Parkinson's disease.
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- Physicochemical and Storage Information
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- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 267.34 |
|---|---|
| Molecular Formula | C12H13N.CH4O3S |
| CAS No. | 161735-79-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 53 mg/mL (198.2 mM)r |
| Water: 53 mg/mL (198.2 mM)r | |
| Ethanol: 53 mg/mL (198.2 mM) | |
| Solubility In Vivo | Saline: 30 mg/mL |
| SMILES Code | CS(=O)(=O)O.C#CCNC1CCC2=CC=CC=C1 |
| Synonyms | TVP101; TV 1030, TVP1022; Agn-1135; Azilect; TV-1030; HSDB 7699; Rasagiline; Racemic rasagiline; Agn 1135; Agn1135; rasagiline Mesylate; Rasagiline mesilate; Agilect; TVP-1022; TVP-101; N-2-propynyl-1-indanamine N-propargyl-1-aminoindan mesylate; rasagiline; rasagiline hydrochloride; TVP 101; TVP 1022; 1-Indanamine, N-2-propynyl-, (R)-; N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-amine methanesulfonate |
| Protocol | In Vitro | Rasagiline (0.25 nM; 96 hours) significantly increases the proliferation rates of SH-SY5Y and 1242-MG upon Dexamethasone (10 µM) treatment. |
|---|---|---|
| In Vivo | Rasagiline is neuroprotective in a transgenic model of multiple system atrophy. Motor behavioural tests show improvements in motor deficits associated with 2.5 mg/kg Rasagiline therap. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.7406 mL | 18.7028 mL | 37.4056 mL | 74.8111 mL |
| 5mM | 0.7481 mL | 3.7406 mL | 7.4811 mL | 14.9622 mL |
| 10mM | 0.3741 mL | 1.8703 mL | 3.7406 mL | 7.4811 mL |
| 20mM | 0.1870 mL | 0.9351 mL | 1.8703 mL | 3.7406 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.