Ranirestat
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1550 | To Be Confirmed |
| 200mg | $2325 | To Be Confirmed |
| 500mg | $3920 | To Be Confirmed |
: Cat #: V12303 CAS #: 147254-64-6 Purity ≥ 99%
Description: Ranirestat (AS-3201; SX-3201) is a novel, oral and potent aldose reductase inhibitor with the potential for the treatment of diabetic neuropathy.
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| Molecular Weight (MW) | 420.19 |
|---|---|
| Molecular Formula | C17H11BrFN3O4 |
| CAS No. | 147254-64-6 |
| SMILES Code | O=C(N(CC1=CC=C(Br)C=C1F)C2=O)C3=CC=CN3[C@]2(C4)C(NC4=O)=O |
| Synonyms | SX-3201; SX3201; SX 3201; Ranirestat; AS-3201; AS3201; AS 3201; |
| Protocol | In Vitro | Ranirestat concentration-dependently inhibits sorbitol accumulation in rat erythrocytes and sciatic nerves incubated in the high concentration (500 mg/dl) of glucose. The potency of Ranirestat inhibition of sorbitol accumulation is similar between rat erythrocytes and sciatic nerves with IC50 values of 0.010 μM and 0.041 μM, respectively. |
|---|---|---|
| In Vivo | Ranirestat (0.03-1.0 mg/kg; oral administration; once daily; for 3 weeks; male STD-Wistar rats) treatment dose-dependently decreases the elevated sorbitol and fructose levels in the rat sciatic nerves without affecting blood glucose level. Ranirestat also improves the STZ-induced decrease in motor nerve conduction velocity (MNCV) in a dose-dependent manner. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3799 mL | 11.8994 mL | 23.7988 mL | 47.5975 mL |
| 5mM | 0.4760 mL | 2.3799 mL | 4.7598 mL | 9.5195 mL |
| 10mM | 0.2380 mL | 1.1899 mL | 2.3799 mL | 4.7598 mL |
| 20mM | 0.1190 mL | 0.5950 mL | 1.1899 mL | 2.3799 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
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V1
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C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.