Radiprodil (RGH-896)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $1999 | Check With Us |
| 1g | $2800 | Check With Us |
| 5g | $8400 | Check With Us |
: Cat #: V8096 CAS #: 496054-87-6 Purity ≥ 98%
Description: Radiprodil, formerly known as RGH-896, is an orally bioavailable and selective NMDA receptors antagonist which was evaluated as potential treatmen of neuropathic pain associated with diabetic peripheral neuropathy (DPNP).
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| Molecular Weight (MW) | 397.40 |
|---|---|
| Molecular Formula | C21H20FN3O4 |
| CAS No. | 496054-87-6 |
| Protocol | In Vitro | Preincubation with Radiprodil (10 nM) restores long-term potentiation (LTP) in the presence of Aβ1-42, 3NTyr10-Aβ and Aβ1-40, but not AβpE3[2]. As for LTP, Radiprodil (10 nM) reverses the synaptic toxicity of 3NTyr-AβAβ1-40 and Aβ1-42 but not that AβpE3-42 |
|---|---|---|
| In Vivo | Radiprodil could block NMDA currents in Mg2+ insensitive variants, with potencies similar to those obtained without Mg2+ |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5164 mL | 12.5818 mL | 25.1636 mL | 50.3271 mL |
| 5mM | 0.5033 mL | 2.5164 mL | 5.0327 mL | 10.0654 mL |
| 10mM | 0.2516 mL | 1.2582 mL | 2.5164 mL | 5.0327 mL |
| 20mM | 0.1258 mL | 0.6291 mL | 1.2582 mL | 2.5164 mL |
The molarity calculator equation
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.