R1487 HCl

This product is for research use only, not for human use. We do not sell to patients.

R1487 HCl
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
5mg$903-6 Days
10mg$1403-6 Days
25mg$2403-6 Days
50mg$3703-6 Days
100mg$5103-6 Days
250mg$7703-6 Days
500mg$10703-6 Days

Cat #: V4141 CAS #: 449808-64-4 Purity ≥ 99%

Description: R1487 HCl is a novel, potent, orally bioavailable, and highly selective inhibitor of p38α mitogen-activated protein kinase. IIt was discovered during the development of a new series of p38α inhibitors and advanced into a phase 2 clinical trial for rheumatoid arthritis. The pharmacokinetic characteristics of R1487 are good.

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Molecular Weight (MW)424.833
Molecular FormulaC19H19ClF2N4O3
CAS No.449808-64-4
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.

SynonymsR-1487 HCl; R1487 HCl; R 1487 HCl
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.3539 mL11.7693 mL23.5387 mL47.0773 mL
5mM0.4708 mL2.3539 mL4.7077 mL9.4155 mL
10mM0.2354 mL1.1769 mL2.3539 mL4.7077 mL
20mM0.1177 mL0.5885 mL1.1769 mL2.3539 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.