Quisinostat HCl

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$1200	Check With Us
500mg	$1800	Check With Us
1g	$2700	Check With Us

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Cat #: V13533 CAS #: 1083078-98-1 Purity ≥ 99%

Description: Quisinostat HCl (formerly JNJ-26481585; JNJ 26481585; JNJ26481585), the hydrochloride salt of Quisinostat, is an orally bioavailable, 2nd generation, hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antitumor activity.

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Molecular Weight (MW)	467.4
Molecular Formula	C21H28Cl2N6O2
CAS No.	1083078-98-1
SMILES Code	O=C(C1=CN=C(N2CCC(CNCC3=CN(C)C4=C3C=CC=C4)CC2)N=C1)NO.[H]Cl.[H]Cl
Synonyms	Quisinostat hydrochloride; quisinostat dihydrochloride; JNJ26481585; JNJ-26481585; JNJ 26481585; JNJ-26481585-AAC; Quisinostat HCl;

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.1395 mL	10.6975 mL	21.3950 mL	42.7899 mL
5mM	0.4279 mL	2.1395 mL	4.2790 mL	8.5580 mL
10mM	0.2139 mL	1.0697 mL	2.1395 mL	4.2790 mL
20mM	0.1070 mL	0.5349 mL	1.0697 mL	2.1395 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.