QNZ46

This product is for research use only, not for human use. We do not sell to patients.

QNZ46
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$925Check With Us
500mg$1280Check With Us
1g$1920Check With Us

Cat #: V2968 CAS #: 1237744-13-6 Purity ≥ 98%

Description: QNZ46 is a novel non-competitive and NR2C/NR2D-selective NMDA receptor antagonist with IC50 values of 3, 6, 229, and >300, >300 μM for NR2D, NR2C, NR2A, NR2B, and GluR1, respectively.

References: Hansen KB, et al. Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors. J Neurosci. 2011 Mar 9;31(10):3650-3661.

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Promise
Molecular Weight (MW)443.41
Molecular FormulaC24H17N3O6
CAS No.1237744-13-6
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: ≥ 4.4 mg/mL, < 8 mg/mLr
Water: <1 mg/mLr
Ethanol: <1 mg/mL
SynonymsQNZ46; QNZ-46; QNZ 46.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.2552 mL11.2762 mL22.5525 mL45.1050 mL
5mM0.4510 mL2.2552 mL4.5105 mL9.0210 mL
10mM0.2255 mL1.1276 mL2.2552 mL4.5105 mL
20mM0.1128 mL0.5638 mL1.1276 mL2.2552 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.