Pyrogallol
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5g | $60 | Check With Us |
| 10g | $85 | Check With Us |
| 20g | $127 | Check With Us |
: Cat #: V7824 CAS #: 87-66-1 Purity ≥ 99%
Description: Pyrogallol is a novel and potent organic compound.
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| Molecular Weight (MW) | 126.11 |
|---|---|
| Molecular Formula | C6H6O3 |
| CAS No. | 87-66-1 |
| SMILES Code | OC1=C(O)C(O)=CC=C1 |
| Synonyms | Benzene-1,2,3-triol; C.I. 76515; Fouramine Brown AP; NSC 503; Pyrogallol; 2,3-Dihydroxyphenol; |
| Protocol | In Vitro | The effect of Pyrogallol on human pulmonary fibroblast (HPF) cell viability and necrotic cell death is examined. For these experiments, 0, 50 or 100 µM Pyrogallol is used to differentiate the levels of cell viability inhibition or death with or without a given MAPK inhibitor. Treatment with 50 and 100 µM Pyrogallol decreases HPF viability by ~40 and 65% at 24 h, respectively. Treatment with an MEK inhibitor slightly enhances the inhibition of cell viability in 50 µM Pyrogallol-treated HPF cells, whereas treatment with a p38 inhibitor mildly attenuates the inhibition of viability. In 100 µM Pyrogallol-treated HPF cells, all the MAPK inhibitors increase the inhibition of viability to a certain extent, with treatment with the p38 inhibitor alone augmenting HPF control cell viability. Necrotic cell death is determined by measuring lactate dehydrogenase (LDH) release from cells. While treatment with 50 µM Pyrogallol does not affect LDH release from HPF cells, 100 µM Pyrogallol significantly increases LDH release. Pyrogallol (PG) is a reductant that is able to generate free radicals, in particular superoxide anions (O2•-), so has frequently been used as a photographic developing agent and in the hair dying industry. Pyrogallol inhibits Calu-6 and A549 lung cancer cell growth via apoptosis and depletion of glutathione (GSH). Pyrogallol (PG) induces apoptosis in lung cancer cells via the overproduction of O2•- and affects mitogen activated protein kinases (MAPKs) in these cells. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 7.9296 mL | 39.6479 mL | 79.2959 mL | 158.5917 mL |
| 5mM | 1.5859 mL | 7.9296 mL | 15.8592 mL | 31.7183 mL |
| 10mM | 0.7930 mL | 3.9648 mL | 7.9296 mL | 15.8592 mL |
| 20mM | 0.3965 mL | 1.9824 mL | 3.9648 mL | 7.9296 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.