PTC-209 HBr
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $600 | Check With Us |
| 250mg | $1120 | Check With Us |
| 500mg | $1680 | Check With Us |
: Cat #: V1932 CAS #: 1217022-63-3 Purity ≥ 98%
Description: PTC-209 HBr (PTC209) is the hydrobromide salt of PTC-209. PTC-209 is a novel, potent and selective BMI-1 inhibitor with IC50 of 0.5 μM and with potential anticancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 576.10 |
|---|---|
| Molecular Formula | C17H13Br2N5OS.HBr |
| CAS No. | 1217022-63-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mL (173.6 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| Synonyms | PTC209 HBr; PTC 209; PTC-209 Hydrobromide |
| Protocol | In Vitro | PTC-209 (0.01-10 µM; 24-72 hours) induces a concentration- and time-dependent decrease in the cellular viability of all cell lines tested. PTC-209 (1-2.5 μM) inhibits STAT3 phosphorylation in A549 lung cancer cells and MDA-MB-231 breast cancer cells. |
|---|---|---|
| In Vivo | PTC-209 (60 mg/kg body weight; subcutaneously; once a day for 11 days) significantly reduces tumor volume. | |
| Animal model | Nude mice (male, aged 8-10 weeks, HCT1116 cell-derived tumor) | |
| Dosages | 60 mg/kg body weight | |
| Administration | Subcutaneously; once a day for 11 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.7358 mL | 8.6790 mL | 17.3581 mL | 34.7162 mL |
| 5mM | 0.3472 mL | 1.7358 mL | 3.4716 mL | 6.9432 mL |
| 10mM | 0.1736 mL | 0.8679 mL | 1.7358 mL | 3.4716 mL |
| 20mM | 0.0868 mL | 0.4340 mL | 0.8679 mL | 1.7358 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.