Proxalutamide
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1245 | To Be Confirmed |
| 250mg | $2345 | To Be Confirmed |
| 500mg | $3515 | To Be Confirmed |
: Cat #: V7564 CAS #: 1398046-21-3 Purity ≥ 99%
Description: Proxalutamide (GT0918; GT-0918) is a novel, oral and potent androgen receptor/AR antagonist or nonsteroidal antiandrogen (NSAA).
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| Molecular Weight (MW) | 517.5026 |
|---|---|
| Molecular Formula | C24H19F4N5O2S |
| CAS No. | 1398046-21-3 |
| SMILES Code | N#CC1=CC=C(N(C(N(C2=CC=C(CCCC3=NC=CO3)N=C2)C4(C)C)=S)C4=O)C(F)=C1C(F)(F)F |
| Synonyms | Proxalutamide; GT 0918; GT0918; GT-0918 |
| Protocol | In Vitro | Proxalutamide can overcome the resistance of prostatic cancer cells by downregulating the expression of AR genes |
|---|---|---|
| In Vivo | The elimination half-life (t1/2) of proxalutamide in rats is approximately 2 h regardless of whether it is administered by the intragastric or the intravenous route. The maximum plasma concentration of proxalutamide (Cmax) could reach 2 μg/mL or higher, and the oral absolute bioavailability (F) was approximately 80% | |
| Animal model | Rats | |
| Dosages | 20 mg/kg (Pharmacokinetic Analysis) | |
| Administration | Intragastrically. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9324 mL | 9.6618 mL | 19.3236 mL | 38.6471 mL |
| 5mM | 0.3865 mL | 1.9324 mL | 3.8647 mL | 7.7294 mL |
| 10mM | 0.1932 mL | 0.9662 mL | 1.9324 mL | 3.8647 mL |
| 20mM | 0.0966 mL | 0.4831 mL | 0.9662 mL | 1.9324 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.