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Protirelin (Synthetic thyrotropin-releasing factor)

This product is for research use only, not for human use. We do not sell to patients.

Protirelin (Synthetic thyrotropin-releasing factor)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
500mg$1150To Be Confirmed
1g$1650To Be Confirmed
5g$4175To Be Confirmed

Cat #: V5206 CAS #: 24305-27-9 Purity ≥ 98%

Description: Protirelin (Thyrel TRH) is a novel, potent and highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

References: Van Sinay E, et al. Evolutionarily conserved TRH neuropeptide pathway regulates growth in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4065-E4074.

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Molecular Weight (MW)362.38
Molecular FormulaC16H22N6O4
CAS No.24305-27-9
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
SMILES CodeO=C(N)[C@H]1N(C([C@H](CC2=CNC=N2)NC([C@H](CC3)NC3=O)=O)=O)CCC1
SynonymsProtirelin; Antepan; Hirtonin; A-38579; A 38579; A38579; Thyrel TRH
ProtocolIn VivoProtirelin (TRH) is an evolutionarily ancient neuropeptide, having its origin before the divergence of protostomes and deuterostomes, and may ancestrally have been involved in the control of postembryonic growth and reproduction.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.7595 mL13.7977 mL27.5953 mL55.1907 mL
5mM0.5519 mL2.7595 mL5.5191 mL11.0381 mL
10mM0.2760 mL1.3798 mL2.7595 mL5.5191 mL
20mM0.1380 mL0.6899 mL1.3798 mL2.7595 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.