This product is for research use only, not for human use. We do not sell to patients.
| Size | Price | Stock |
|---|---|---|
| 100mg | $80 | 3-6 Days |
| 250mg | $120 | 3-6 Days |
| 500mg | $180 | 3-6 Days |
: Cat #: V4063 CAS #: 1448189-80-7 Purity ≥ 99%
Description: Protein degrader 1 HCl (hydrochloride) or PROTAC-VHL-ligand is a novel and potent small molecule ligand for VHL (Von Hippel-Lindau), which is an E3 ligase which has been targeted in many PROTAC (proteolysis-targeting chimeras) degraders. Small molecule-induced protein degradation is an attractive strategy for the development of chemical probes. One method for inducing targeted protein degradation involves the use of PROTACs, heterobifunctional molecules that can recruit specific E3 ligases to a desired protein of interest. PROTACs have been successfully used to degrade numerous proteins in cells, but the peptidic E3 ligase ligands used in previous PROTACs have hindered their development into more mature chemical probes or therapeutics.
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| Molecular Weight (MW) | 467.02 |
|---|---|
| Molecular Formula | C₂₂H₃₁ClN₄O₃S |
| CAS No. | 1448189-80-7 |
| Storage | Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Synonyms | Protein degrader 1 hydrochloride; Protein degrader 1 TFA;VH032-NH2 TFA; VHL ligand 1 TFA;Protein degrader 1 TFA , VHL-7526 TFA; VHL-7526; VHL7526; VHL 7526 |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1412 mL | 10.7062 mL | 21.4124 mL | 42.8247 mL |
| 5mM | 0.4282 mL | 2.1412 mL | 4.2825 mL | 8.5649 mL |
| 10mM | 0.2141 mL | 1.0706 mL | 2.1412 mL | 4.2825 mL |
| 20mM | 0.1071 mL | 0.5353 mL | 1.0706 mL | 2.1412 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.