PROTAC Linker 4
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $710 | Check With Us |
| 500mg | $999 | Check With Us |
| 1g | $1499 | Check With Us |
: Cat #: V4743 CAS #: 1799506-30-1 Purity ≥ 98%
Description: PROTAC Linker 4 is a non-peptide (small molecule) linker used in the synthesis of chloroalkane-containing PROTACs (HaloPROTACs).
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 370.87 |
|---|---|
| Molecular Formula | C₁₆H₃₁ClO₇ |
| CAS No. | 1799506-30-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | ClCCCCCCOCCOCCOCCOCCOCC(O)=O |
| Synonyms | Cl-C6-PEG4-O-CH2COOH; PROTAC Linker 4; 1799506-30-1; 21-Chloro-3,6,9,12,15-pentaoxahenicosan-1-oic acid |
| Protocol | In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.6964 mL | 13.4818 mL | 26.9636 mL | 53.9273 mL |
| 5mM | 0.5393 mL | 2.6964 mL | 5.3927 mL | 10.7855 mL |
| 10mM | 0.2696 mL | 1.3482 mL | 2.6964 mL | 5.3927 mL |
| 20mM | 0.1348 mL | 0.6741 mL | 1.3482 mL | 2.6964 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.