Promegestone
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $500 | To Be Confirmed |
| 500mg | $880 | To Be Confirmed |
| 1g | $1320 | To Be Confirmed |
: Cat #: V5585 CAS #: 34184-77-5 Purity ≥ 99%
Description: Promegestone (R-5020; RU-5020; trade name Surgestone) is a progestin medication and a synthetic progestogen acting as an agonist of the progesterone receptor.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 326.47 |
|---|---|
| Molecular Formula | C22H30O2 |
| CAS No. | 34184-77-5 |
| SMILES Code | C[C@@]12[C@](C(CC)=O)(C)CC[C@@]1([H])[C@]3([H])CCC4=CC(CCC4=C3CC2)=O |
| Synonyms | Promegestone; U 56217; U-56217; U56217; R 5020; R-5020; R5020; RU 5020; RU-5020; RU5020; Surgestone; |
| Protocol | In Vitro | Promegestone is inactive in HELN cells that express luciferase but no functional receptor. Promegestone (R-5020; 1 nM) is efficient ligand with a full agonist response profile and a low EC50 of 0.33 nM) in HELN-hPR while it only partially induced luciferase activity in U2OS-zfPR (EC50=1.93 nM). |
|---|---|---|
| In Vivo | Promegestone (R-5020; 8 mg/kg; intramuscularly)-treated pregnant mice on day 18 postbreeding has the least deterioration in extracellular collagen (lowest OD) and highest cell density compared to other groups on the day before birth. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.0631 mL | 15.3153 mL | 30.6307 mL | 61.2614 mL |
| 5mM | 0.6126 mL | 3.0631 mL | 6.1261 mL | 12.2523 mL |
| 10mM | 0.3063 mL | 1.5315 mL | 3.0631 mL | 6.1261 mL |
| 20mM | 0.1532 mL | 0.7658 mL | 1.5315 mL | 3.0631 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.