ML414 (also known NGI-1) is a novel and cell-permeable inhibitor of oligosaccharyltransferase (OST), which is a hetero-oligomeric enzyme that exists in multiple isoforms and transfers oligosaccharides to recipient proteins. ML414 was identified from a cell-based high-throughput screen and lead-compound-optimization campaign. In non-small-cell lung cancer cells, NGI-1 blocks cell-surface localization and signaling of the epidermal growth […]

ESI-09 (ESI09) is a non-noncyclic nucleotide and specific inhibitor of exchange protein directly activated by cAMP (EPAC) with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively. As an EPAC antagonist, it displays >100-fold selectivity over PKA. ESI-09 (25 µM) reduced EPAC1 and EPAC2 GEF activity to basal levels in the presence […]

Rupintrivir (AG-7088) is a novel, selective and irreversible rhinovirus 3C protease inhibitor potentially for the treatment of human rhinovirus-HRV infection.