Verteporfin (also known as DB00460, CL318952, BPD-MA, BpdMA, Benzoporphyrin derivative monoacid ring A or BPD-MA) is a novel and potent second-generation photosensitizing agent derived from porphyrin in endothelial cells. It can be used for angiographic visualization of choroidal vessels and CNV.

Vadimezan (DMXAA, NSC-640488, AS1404, ASA-404) is a potent vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with potential antitumor activity. It inhibits VDA and DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively.

Plinabulin (formerly also known as NPI-2358) is a novel and potent vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells. It demonstrate significant in vivo antitumor efficacy in human plasmacytoma mouse xenograft models. Plinabulin is a first-in-class and selective immunomodulating microtubule-binding agent (SIMBA), which binds in the vicinity of the […]