Octreotide acetate (SMS201-995; Sandostatin, SMS201995; Samilstin; Sandostatina; Octreotide-LAR; Longastatin), the acetate salt of Octreotide, is an octapeptide and somatostatin analogue acting as an agonist for sst2, sst3 and sst5 somatostatin receptors.

Pasireotide (SOM230; Signifor) is a cyclohexapeptide-based somatostatin mimic approved for the treatment of Cushing’s disease.

MK-4256 is a novel, potent and selective SSTR3 (somatostatin subtype receptor 3) antagonist with IC50s of 0.66 nM and 0.36 nM in human and mouse receptor binding assays, respectively.