CMK is a novel, potent and irreversible RSK2 kinase inhibitor which exhibits similar potency but less chemical stability compared with FMK.

Pluripotin (also known as SC1; SC-1) is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP as well as a sustainer of mES self-renewal.

BIX 02565 is a novel RSK2 inhibitor with IC50 of 1 nM.

SL0101 (SL 0101-1) a kaempferol glycoside isolated from the tropical plant F. refracta, is a novel, potent, cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC50 of 89 nM.

LJH685 is a potent and specific RSK inhibitor.