BRM/BRG1 ATP Inhibitor-1 is an orally bioactive inhibitor of Brahma Homolog (BRM)/SMARCA2 ATPase with anticancer activity and has potential to be used for the treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers.

Dot1L-IN-4 is a novel and potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor.

BRD-5648 (also known as (R)-BRD-0705) is an inactive (R)-enantiomer of BRD-0705.

LFM-A13 (LFM-A1-3) is a novel, potent and specific Bruton’s tyrosine kinase (BTK) inhibitor with potential anticancer activity. It inhibits BTK with an IC50 of 2.5 μM, and shows >100-fold selectivity over other protein kinases such as JAK1, JAK2, HCK, EGFR,and IRK. LFM-A13 inhibited recombinant BTK expressed in a baculovirus expression vector system. Besides its remarkable […]

DUPA belongs to a class of glutamate ureas.

Cinobufotalin is a steroid glycoside that reduces SRC-3 protein levels in MCF-7 breast cancer cells,is extracted from the skin secretions of the giant toads.

Glycyroside is a isoflavone diglycoside isolated from Glycyrrhiza eurycarpa P. C. Li.

NITD-349 is a novel and potent MmpL3 inhibitor, it shows highly potent anti-mycobacterial activity (MIC50=23 nM) against virulent Mycobacterium tuberculosis H37Rv.

Fangchinoline is a novel and potent kinase inhibitor.

MAC-545496 is novel and potent inhibitor of GraR (glycopeptide-resistance-associated protein R) with nanomolar activity.