Ilginatinib (NS018; NS-018) HCl, the hydrochloride salt form of NS-018, is an oral and potent JAK2 inhibitor with potential anticancer activity. It inhibits JAK2 with an IC50 of 0.72 nM, and exhibits 46-, 54-, and 31-fold selectivity for JAK2 over JAK1 (IC50, 33 nM), JAK3 (IC50, 39 nM), and Tyk2 (IC50, 22 nM). JAK2/Src inhibitor […]

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