Pevonedistat HCl (MLN4924; TAK924), the hydrochloride salt of Pevonedistat, is an inhibitor of Nedd8 (Neural precursor cell expressed, developmentally down-regulated 8) activating enzyme (NAE) with IC50 of 4 nM.

Pevonedistat (previously known as MLN-4924; TAK-924) is a potent and selective small molecule inhibitor of Nedd8 (Neural precursor cell expressed, developmentally down-regulated 8) activating enzyme (NAE) with anticancer activity.

ZM223 is a potent non-covalent NEDD8 activating enzyme (NAE) inhibitor, orally bioavailable.