Mps1-IN-2 is a novel, ATP-competitive and potent Mps1 (monopolar spindle)/Plk1 (Polo Like Kinase 1) inhibitor with potential anticancer activity.

Mps1-IN-1 is a novel, ATP-competitive, selective and potent Mps1 kinase inhibitor with antitumor activity.

TC-Mps1-12 is a novel, selective and potent monopolar spindle 1 (Mps1) inhibitor with anticancer activity.

BAY 1217389 (BAY-1217389) is a novel, potent, orally bioavailable and selective inhibitor of the serine/threonine kinase monopolar spindle 1 (MPS1) (IC50 < 10 nM) with potential cancer activity by selectively binding to and inhibiting the activity of Mps1.

Empesertib (also known as BAY 1161909) is a novel, potent, orally bioavailable, and selective inhibitor of serine/threonine kinase Mps1 (monopolar spindle 1) with an IC50 of < 1 nM.