Necrosulfonamide HCl is a potent and cell-permeable MLKL (mixed lineage kinase domain-like) inhibitor.

TC13172 (TC-13172) is a mixed Lineage Kinase Domain-Like protein (MLKL) inhibitor with single nanomolar potency.

Necrosulfonamide is a potent and highly specific and potent necrosis inhibitor which blocks mixed lineage kinase domain-like protein (MLKL).

GW806742X is a novel and potent inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL pseudokinase domain with a Kd value of 9.3 μM and has anti-necroptosis activity.

GNE-3511 is a novel, highly potent and selective zipper kinase (e.g. DLK, MAP3K12) inhibitor with IC50 of 0.107 uM for DLK.