BIX02188 (BIX-02188), an indolinone analog, is a novel, highly potent and selective MEK5 inhibitor with the potential to relieve neuropathic pain.

APS-2-79 (APS-279) is a potent antagonist of MAPK (mitogen-activated protein kinase) with antitumor activity.

BIX02189 is a novel, potent and selective inhibitor of MEK5 with important biological activity.

Trans-Zeatin is a plant hormone /cytokinin that plays an important role in cell growth, differentiation, and division, it promotes growth of lateral buds, stimulates seed germination and seedling growth, and induces cell division.

PD318088 (PD-318088), an analog of PD184352, is a novel, potent and non-ATP competitive (allosteric) MEK1/2 inhibitor with potential anticancer activity.

Pimasertib (formerly SAR-245509, AS-703026, MSC-1936369B) is a selective, orally bioavailable and non-ATP competitive (allosteric) inhibitor of MEK1/2 with potential anticancer activity.

PD184352 (PD-184352; CI-1040), an analog of benzhydroxamate, is an orally bioactive, specific, allosteric/non-ATP competitive MEK1/2 inhibitor with potential anticancer activity.

GW284543 (also known as GW-284543; UNC10225170; UNC-10225170) is a novel, potent and selective MEK5 inhibitor with potential usefulness in cancer treatment.

Trans-Zeatin is a plant hormone /cytokinin that plays an important role in cell growth, differentiation, and division, it promotes growth of lateral buds, stimulates seed germination and seedling growth, and induces cell division. trans-Zeatin is a plant cytokinin.

BIX02189 is a novel, potent and selective MEK5 inhibitor with an IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with an IC50 of 59 nM.