AM-2394 is a novel, potent and selective Glucokinase activator/agonist (GKA), which catalyzes the phosphorylation of glucose to glucose-6-phosphate.

LY2608204, an investigational drug, is a novel and potent activator of glucokinase (GK) with EC50 of 42 nM.

Miglitol (formerly known as BAY1099; BAY-m1099; Seibule; Diastabol; Glyset) is a novel, potent, orally bioavailable anti-diabetic drug that acts by inhibiting the ability of patients to breakdown complex carbohydrates into glucose.