Astragaloside A (also called Astragaloside IV) is the major pure and active form of saponin isolated from Astragalus membranaceus in Traditional Chinese Medicin, and has been widely used for the treatment of cardiovascular diseases (e.g. ischemia) and kidney disease.
Lacidipine (GX-1048, GR-43659X, SN-305; GX1048, GR43659X, SN305; Caldine, Lacimen, Lacipil, Midotens, Motens) is a potent and 3rd-generation L-type CCB (calcium channel blocker) that has been approved in 1990s for treating high blood pressure.
Nisoldipine (BAY-K-5552; Bay K-5552, Sular, Baymycard, Nisocor, Syscor) is a novel CCB-calcium channel blocker of the dihydropyridine (DHP) class with vasodilating and antihypertensive effects.
(-)-Praeruptorin A [(9R,10S) isomer] is a naturally occuring di-esterified coumarin derivative extracted from the dried roots of Peucedanum praeruptorumDunn, which is a traditional Chinese medicine used for the treatment of cough with thick sputum and dyspnea.
Lumacaftor (formerly VX809; VRT-826809; VRT826809; VX-809; Orkambi) is a potent and orally bioavailable CFTR (cystic fibrosis transmembrane conductance regulator) corrector with antifibrotic effects.
Ranolazine 2HCl (known also as Ranolazine diHydrochloride), the diHCl salt of ranolzaine (RS43285; CVT303), is a an anti-angina drug which acts as a potent calcium uptake inhibitor via the sodium/calcium channel, it is used to treat chronic angina.
Ivacaftor (formerly also known as VX-770; trade name: KALYDECO and Symdeko) is a potent and orally bioactive potentiator of CFTR (cystic fibrosis transmembrane conductance regulator) with potential anti-fibrotic activity.
ABT-639 is a new potent, peripherally acting, selective T-type Ca2+ channel blocker that blocks recombinant human T-type (Cav3.2) Ca2+ channels in a voltage-dependent fashion (IC50=2 μM) and attenuates low voltage-activated (LVA) currents in rat DRG neurons (IC50=8 μM).
Triamcinolone acetonide (Acetospan; Adcortyl A; AllerNaze; Kenalone; Nasacort; Aristocort; Aristoderm. Aristogel) is a potent and synthetic glucocorticoid with improved anti-inflammatory activities.
Prednisolone (AKOS-016010152; AK-115681; Predsol; Pediapred) is an approved medication acting as a potent and synthetic glucocorticoid with anti-inflammatory and immunomodulatory properties.