Atabecestat (formerly known as JNJ-54861911) is a novel potent, oral, and brain-penetrant BACE1 inhibitor that inhibits β-site amyloid precursor protein cleaving enzyme 1 (BACE1), an enzyme up-regulated in Alzheimer’s disease.

Aloeresin D is a novel and potent chromone glycoside isolated from Aloe vera.

LX2343, discovered by high throughout screening, is a small molecule compound that can effectively reverse the streptozocin (STZ)-induced neuronal apoptosis and tau hyperphosphorylation in vitro and in vivo.

LY2811376 (LY-2811376; LY 2811376) is a novel, potent, selective and the first orally bioavailable non-peptidic β-secretase (BACE1) inhibitor with the potential for the treatment of Alzheimer’s Disease (AD).

Verubecestat (formerly known as MK8931; SCH-900931) is a beta-secretase 1 and BACE1 inhibitor that is in Phase 3 clinical trial for treatment of Alzheimer’s disease.

PF-06751979 (PF06751979) is a novel, highly potent, brain penetrant, and selective inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) with the potential to be used for the treatment of Alzheimer’s disease. It inhibits BACE1 with an IC50 of 7.3 nM in BACE1 binding assay. PF-06751979 displays excellent brain penetration, potent in vivo efficacy, […]