BEC HCl is a novel and potent Arginase II inhibitor (Ki = 0.31 μM), the binding is slow and competitive.

Numidargistat 2HCl (CB-1158 B, INCB-01158; INCB001158) is a novel, potent and orally bioavailable immunomodulating agent acting as an arginase inhibitor with IC50s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2, respectively.

Numidargistat (CB-1158 B, INCB-01158) is a novel, potent and orally bioavailable immunomodulating agent acting as an arginase inhibitor with anticancer effects.