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| Size | Price | Stock |
|---|---|---|
| 25mg | $630 | 3-6 Days |
| 50mg | $1080 | 3-6 Days |
| 100mg | $1800 | 3-6 Days |
: Cat #: V92504 CAS #: 2754408-94-9 Purity ≥ 99%
Description: Claturafenib (also known as PF-07799933 andARRY-440) is a novel, brain-penetrant, orthosteric, selective, pan-mutant BRAF inhibitor with anticancer activity. PF-07799933 treatment was associated with antitumor activity against BRAFV600- and non-V600-mutant cancers preclinically and in treatment-refractory patients, and PF-07799933 could be safely combined with a MEK inhibitor. The novel, rapid pharmacokinetics (PK)-informed dose escalation design provides a new paradigm for accelerating the testing of next-generation targeted therapies early in clinical development.PF-07799933 exhibited broad inhibition of pERK levels in cell lines harboring Class I (IC50 = 0.7–7 nmol/L), II (10–14 nmol/L), III (0.8–7.8 nmol/L), and indel (113–179 nmol/L) mutants, acquired BRAF p61 splice variant (59 nmol/L), and acquired NRASQ61K (16 nmol/L), but significantly spared pERK in BRAF wild-type cells (≥9,800 nmol/L).
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| Molecular Weight (MW) | 490.31 |
|---|---|
| Molecular Formula | C18H15Cl2F2N5O3S |
| CAS No. | 2754408-94-9 |
| Storage | Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Synonyms | 2754408-94-9; PF07799933; Claturafenib (USAN); PF-07799933; SCHEMBL25280690; N-(2-chloro-3-((5-chloro-3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)-4-fluorophenyl)-3-fluoroazetidine-1-sulfonamide |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0395 mL | 10.1976 mL | 20.3953 mL | 40.7905 mL |
| 5mM | 0.4079 mL | 2.0395 mL | 4.0791 mL | 8.1581 mL |
| 10mM | 0.2040 mL | 1.0198 mL | 2.0395 mL | 4.0791 mL |
| 20mM | 0.1020 mL | 0.5099 mL | 1.0198 mL | 2.0395 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.