Pebezertinib

This product is for research use only, not for human use. We do not sell to patients.

Pebezertinib
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
5mg$903-6 Days
10mg$1203-6 Days
50mg$3303-6 Days
100mg$5603-6 Days
email: [email protected]        [email protected]

Cat #: V92040 CAS #: 2769954-39-2 Purity ≥ 99%

Description: Pebezertinib (BLU 451) is an orally available EGFR inhibitor. Pebezertinib has the ability to penetrate the central nervous system (CNS). Pebezertinib can be used to study non-small cell lung cancer carrying EGFR exon 20 insertions.

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Molecular Weight (MW)497.45
Molecular FormulaC24H19F4N7O
CAS No.2769954-39-2
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

SynonymsBLU 451;LNG-451
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.0103 mL10.0513 mL20.1025 mL40.2050 mL
5mM0.4021 mL2.0103 mL4.0205 mL8.0410 mL
10mM0.2010 mL1.0051 mL2.0103 mL4.0205 mL
20mM0.1005 mL0.5026 mL1.0051 mL2.0103 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Concentration
 
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.