(1S,2S)-ML-SI3 ((+)-trans-ML-SI3)

This product is for research use only, not for human use. We do not sell to patients.

(1S,2S)-ML-SI3 ((+)-trans-ML-SI3)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
1mg$140In Stock
5mg$320In Stock
10mg$500In Stock
email: [email protected]        [email protected]

Cat #: V70122 CAS #: 2563870-87-9 Purity ≥ 99%

Description: (1S,2S)-ML-SI3 is the trans-isomer of ML-SI3 and is a TRPML inhibitor. Its (-)-enantiomer is a potent inhibitor of TRPML1 and TRPML (IC50=1.6 μM/2.3 μM) and a weak inhibitor of TRPML3 (IC50=12.5 μM), while its (+)-enantiomer is Inhibitor of TRPML1 (IC50=5.9 μM), but also an activator of TRPML2 and TRPML3.

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Molecular Weight (MW)429.58
Molecular FormulaC23H31N3O3S
CAS No.2563870-87-9
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Note: This product requires protection from light (avoid light exposure) during transportation and storage.

Synonyms(1S,2S)-ML-SI3; CHEMBL4856175; 2563870-87-9; N-{(1S,2S)-2-[4-(2-methoxyphenyl)piperazin-1-yl]cyclohexyl}benzenesulfonamide; N-[(1S,2S)-2-[4-(2-methoxyphenyl)piperazin-1-yl]cyclohexyl]benzenesulfonamide; DTXSID801336630; BDBM50569843; DA-48624;
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.3279 mL11.6393 mL23.2786 mL46.5571 mL
5mM0.4656 mL2.3279 mL4.6557 mL9.3114 mL
10mM0.2328 mL1.1639 mL2.3279 mL4.6557 mL
20mM0.1164 mL0.5820 mL1.1639 mL2.3279 mL
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.