This product is for research use only, not for human use. We do not sell to patients.
| Size | Price | Stock |
|---|---|---|
| 2mg | $170 | 3-6 Days |
| 5mg | $280 | 3-6 Days |
| 10mg | $450 | 3-6 Days |
| 25mg | $740 | 3-6 Days |
| 50mg | $1140 | 3-6 Days |
| 100mg | $1600 | 3-6 Days |
: Cat #: V3440 CAS #: 1927857-56-4 Purity ≥ 99%
Description: PQR620 is a novel, potent, selective and brain penetrant inhibitor of mTORC1/2 which plays a fundamental role in cell proliferation, differentiation, growth and survival.In lymphomas, the PI3K/AKT/mTOR pathway is a crucial therapeutic target. PQR309 is a dual PI3K/mTOR inhibitor that is in a phase 2 trial (NCT02249429, NCT02723877, NCT02669511) and has demonstrated in vitro anti-lymphoma activity. In solid tumor models, the novel mTORC1/2 inhibitor PQR620 has demonstrated preclinical activity (Beaufils et al., AACR 2016). The novel mTORC1/2 inhibitor PQR620 demonstrated both in vitro and in vivo anti-lymphoma activity. In vivo tests revealed that the PI3K/mTOR dual inhibitor PQR309 and PQR620 can both benefit significantly from the addition of the BCL2 inhibitor venetoclax.
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| Molecular Weight (MW) | 445.47 |
|---|---|
| Molecular Formula | C21H25F2N7O2 |
| CAS No. | 1927857-56-4 |
| Storage | Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Synonyms | PQR-620; PQR 620; PQR620 |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2448 mL | 11.2241 mL | 22.4482 mL | 44.8964 mL |
| 5mM | 0.4490 mL | 2.2448 mL | 4.4896 mL | 8.9793 mL |
| 10mM | 0.2245 mL | 1.1224 mL | 2.2448 mL | 4.4896 mL |
| 20mM | 0.1122 mL | 0.5612 mL | 1.1224 mL | 2.2448 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.