Pomaglumetad (LY404039)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $900 | Check With Us |
| 500mg | $1450 | Check With Us |
| 1g | $2175 | Check With Us |
: Cat #: V1079 CAS #: 635318-11-5 Purity ≥ 98%
Description: Pomaglumetad (LY404039; LY-404039; LY-404,039; LY404,039) is a novel and potent agonist of recombinant human mGlu2/mGlu3 receptors with the potential for the treatment of Schizophrenia.
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- Physicochemical and Storage Information
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- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 235.22 |
|---|---|
| Molecular Formula | C7H9NO6S |
| CAS No. | 635318-11-5 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 1 mg/mL (4.3 mM)rr |
| Water: <1 mg/mLrr | |
| Ethanol: <1 mg/mL | |
| Solubility In Vivo | 30% propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL |
| Synonyms | LY-404039; LY 404039; Pomaglumetad; LY404039; LY-404,039; LY404,039; LY 404,039 |
| Protocol | In Vitro | Functionally, LY404039 potently inhibits Forskolin-stimulated cAMP formation in cells expressing human mGlu2 (EC50 = 23 nM) and mGlu3 receptors (EC50 = 48 nM) |
|---|---|---|
| In Vivo | Following oral administration of LY404039 to fasted rats at doses of 1, 3, or 10 mg/kg, exposure increased proportionally with dose. LY404039 (10 mg/kg; p.o.) treatment shows the Cmax is 1528.5 ng/mL and Tmax is 2 hours in rats |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.2513 mL | 21.2567 mL | 42.5134 mL | 85.0268 mL |
| 5mM | 0.8503 mL | 4.2513 mL | 8.5027 mL | 17.0054 mL |
| 10mM | 0.4251 mL | 2.1257 mL | 4.2513 mL | 8.5027 mL |
| 20mM | 0.2126 mL | 1.0628 mL | 2.1257 mL | 4.2513 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.