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Polymyxin B nonapeptide TFA

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Polymyxin B nonapeptide TFA
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$1250To Be Confirmed
200mg$1875To Be Confirmed
500mg$3160To Be Confirmed

Cat #: V38682 CAS #: 2220175-42-6 Purity ≥ 99%

Description: Polymyxin B nonapeptide TFA, the trifluoroacetic acid of Polymyxin B nonapeptide, is a potent and naturally occurring cyclic peptide derived from Polymyxin B by proteolytic removal of its terminal amino acyl residue.

References: Tsubery H, et al. Structure-function studies of polymyxin B nonapeptide: implications to sensitization of gram-negative bacteria. J Med Chem. 2000 Aug 10;43(16):3085-92.

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Molecular Weight (MW)1533.25
Molecular FormulaC43H74N14O11.5C2HF3O2
CAS No.2220175-42-6
SynonymsPolymyxin B nonapeptide TFA;
ProtocolIn VitroPolymyxin B nonapeptide, a cationic cyclic peptide derived by enzymatic processing from the naturally occurring peptide polymyxin B, is able to increase the permeability of the outer membrane of Gram-negative bacteria toward hydrophobic antibiotics probably by binding to the bacterial lipopolysaccharide (LPS).
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM0.6522 mL3.2610 mL6.5221 mL13.0442 mL
5mM0.1304 mL0.6522 mL1.3044 mL2.6088 mL
10mM0.0652 mL0.3261 mL0.6522 mL1.3044 mL
20mM0.0326 mL0.1631 mL0.3261 mL0.6522 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.