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PNU-282987 S enantiomer free base

This product is for research use only, not for human use. We do not sell to patients.

PNU-282987 S enantiomer free base
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
50mg$2100Check With Us
100mg$3150Check With Us
200mg$4725Check With Us

Cat #: V29474 CAS #: 737727-12-7 Purity ≥ 99%

Description: PNU-282987 S enantiomer free base is a novel and potent α7 nicotinic acetylcholine receptor (α7 nAChR) agonist

References: Bodnar AL, et al. Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. J Med Chem. 2005 Feb 24;48(4):905-8.

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Molecular Weight (MW)264.75
Molecular FormulaC₁₄H₁₇ClN₂O
CAS No.737727-12-7
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.7771 mL18.8857 mL37.7715 mL75.5430 mL
5mM0.7554 mL3.7771 mL7.5543 mL15.1086 mL
10mM0.3777 mL1.8886 mL3.7771 mL7.5543 mL
20mM0.1889 mL0.9443 mL1.8886 mL3.7771 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.