Plevitrexed

This product is for research use only, not for human use. We do not sell to patients.

Plevitrexed
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
1mg$2160To Be Confirmed

Cat #: V19281 CAS #: 153537-73-6 Purity ≥ 99%

Description: Plevitrexed (ZD 9331; BGC9331) is an orally bioavailable thymidylate synthase (TS) inhibitor (antagonist) with Ki of 0.44 nM. Plevitrexed is absorbed through alpha-folate receptors as well as reduced folate carriers. Plevitrexed may be utilized in gastric cancer. Plevitrexed is a reagent for click chemistry. It has Alkyne groups and could undergo CuAAc (copper-catalyzed azide-alkyne cycloaddition reaction) with compounds bearing Azide groups.

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Molecular Weight (MW)532.53
Molecular FormulaC26H25FN8O4
CAS No.153537-73-6
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

SynonymsBGC9331. ZD-9331; BGC 9331; BGC-9331
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.8778 mL9.3891 mL18.7783 mL37.5566 mL
5mM0.3756 mL1.8778 mL3.7557 mL7.5113 mL
10mM0.1878 mL0.9389 mL1.8778 mL3.7557 mL
20mM0.0939 mL0.4695 mL0.9389 mL1.8778 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.