PKM2-IN-1
This product is for research use only, not for human use. We do not sell to patients.
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Size | Price | Stock |
---|---|---|
250mg | $750 | Check With Us |
500mg | $1200 | Check With Us |
1g | $1800 | Check With Us |
Cat #: V3420 CAS #: 94164-88-2 Purity ≥ 98%
Description: PKM2-IN-1 is a novel and potent inhibitor of pyruvate kinase M2 (PKM2) with an IC50 of 2.95 μM.
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- Physicochemical and Storage Information
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- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
Molecular Weight (MW) | 345.48 |
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Molecular Formula | C18H19NO2S2 |
CAS No. | 94164-88-2 |
Storage | -20℃ for 3 years in powder formr |
-80℃ for 2 years in solvent | |
SMILES Code | O=C1C(CSC(N2CCCCC2)=S)=C(C)C(C3=CC=CC=C31)=O |
Synonyms | PKM2 inhibitor; MDK4882; MDK-4882; MDK 4882; compound 3k; PKM2-IN-1 |
Protocol | In Vitro | PKM2-IN-1 (compound 3k) is a pyruvate kinase M2 (PKM2) inhibitor with an IC50 of 2.95±0.53 μM. Results show that most of the tested compounds exhibit some degree of PKM2 inhibition and some compounds, such as PKM2-IN-1 (compound 3k) and 6d, display more potent activity than the positive control shikonin. The representative compounds PKM2-IN-1, 6d display dose-dependent inhibition of PKM2 with less inhibition of PKM1 and PKL like shikonin. Among all tested compounds, the most potent compounds are 3a, PKM2-IN-1 and 3r, which exhibit IC50 values against HCT116 and Hela cells ranging from 0.39 to 0.41 μM, 0.18 to 0.29 μM and 0.18 to 0.38 μM, respectively. |
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These protocols are for reference only. InvivoChem does not
independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added | Mass (the weight of a compound) | |||
---|---|---|---|---|
Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
1mM | 2.8945 mL | 14.4726 mL | 28.9452 mL | 57.8905 mL |
5mM | 0.5789 mL | 2.8945 mL | 5.7890 mL | 11.5781 mL |
10mM | 0.2895 mL | 1.4473 mL | 2.8945 mL | 5.7890 mL |
20mM | 0.1447 mL | 0.7236 mL | 1.4473 mL | 2.8945 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
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Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.