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Pitavastatin Calcium (NK-104)

This product is for research use only, not for human use. We do not sell to patients.

Pitavastatin Calcium (NK-104)
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50g$1350Check With Us
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Cat #: V1859 CAS #: 147526-32-7 Purity ≥ 98%

Description: Pitavastatin calcium (also called NK-104 Calcium; itavastatin or nisvastatin) is a novel and potent drug of the statin class.

References: Mukhtar RY, et al. Pitavastatin. Int J Clin Pract. 2005 Feb;59(2):239-52.

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Molecular Weight (MW)880.98
Molecular FormulaC50H46CaF2N2O8
CAS No.147526-32-7
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 51 mg/mL (57.9 mM)r
Water: <1 mg/mLr
Ethanol: <1 mg/mL
SMILES CodeC1CC1C2=NC3=CC=CC=C3C(=C2C=CC(CC(CC(=O)[O-])O)O)C4=CC=C(C=C4)F.C1CC1C2=NC3=CC=CC=C3C(=C2C=CC(CC(CC(=O)[O-])O)O)C4=CC=C(C=C4)F.[Ca+2]
SynonymsNK-104 Calcium; Livalo; P872441; NK104; Pitavastatin hemicalcium; itavastatin; nisvastatin; P 872441; Nisvastatin; NK 104; NK-104; P-872441
ProtocolIn VitroPitavastatin Calcium inhibits the growth of a panel of ovarian cancer cells, including those considered most likely to represent HGSOC, grown as a monolayers (IC50 = 0.4-5 μM) or as spheroids (IC50=0.6-4 μM).
In VivoPitavastatin Calcium (59 mg/kg; p.o.; twice daily for 28 days) causes significant tumour regression.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.1351 mL5.6755 mL11.3510 mL22.7020 mL
5mM0.2270 mL1.1351 mL2.2702 mL4.5404 mL
10mM0.1135 mL0.5675 mL1.1351 mL2.2702 mL
20mM0.0568 mL0.2838 mL0.5675 mL1.1351 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
×
Volume
 
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
×
 
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.