Pirtobrutinib

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$900	Check With Us
250mg	$1800	Check With Us
500mg	$2700	Check With Us

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Cat #: V2494 CAS #: 2101700-15-4 Purity ≥ 98%

Description: Pirtobrutinib (formerly LOXO-305; LY-3527727; Jaypirca) is a novel, highly selective and non-covalent next generation BTK (Bruton's tyrosine kinase) inhibitor which inhibits diverse BTK C481 substitution mutations.

References: Gomez E B , et al. Loxo-305, a Highly Selective and Non-Covalent Next Generation BTK Inhibitor, Inhibits Diverse BTK C481 Substitution Mutations[J]. Blood, 2019, 134(Supplement_1):4644-4644.

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Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	479.43
Molecular Formula	C22H21F4N5O3
CAS No.	2101700-15-4
SMILES Code	O=C(C1=C(N)N([C@@H](C)C(F)(F)F)N=C1C2=CC=C(CNC(C3=CC(F)=CC=C3OC)=O)C=C2)N
Synonyms	Pirtobrutinib; LOXO-305; LOXO 305; LOXO305; LY 3527727; LY-3527727; LY3527727;

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.0858 mL	10.4291 mL	20.8581 mL	41.7162 mL
5mM	0.4172 mL	2.0858 mL	4.1716 mL	8.3432 mL
10mM	0.2086 mL	1.0429 mL	2.0858 mL	4.1716 mL
20mM	0.1043 mL	0.5215 mL	1.0429 mL	2.0858 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.