Pirfenidone (AMR69)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 2g | $280 | Check With Us |
| 5g | $530 | Check With Us |
| 10g | $795 | Check With Us |
: Cat #: V1364 CAS #: 53179-13-8 Purity ≥ 98%
Description: Pirfenidone (formerly AMR69; S7701, AMR-69; S-7701; trade name: Pirespa; Pirfenex; Deskar, Esbriet) is a potent inhibitor for TGF-β production and TGF-β stimulated collagen production with anti-fibrotic and anti-inflammatory properties.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 185.22 |
|---|---|
| Molecular Formula | C12H11NO |
| CAS No. | 53179-13-8 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 37 mg/mL (199.8 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 37 mg/mL (199.8 mM) | |
| Solubility In Vivo | 2% DMSO+30% PEG 300+ddH2O: 10 mg/mL |
| Synonyms | S-7701, AMR-69; S 7701, AMR69; S7701, AMR-69; AMR 69; Pirfenidone; trade name: Pirespa; Pirfenex; Deskar, Esbriet; Etuary. |
| Protocol | In Vivo | Administration of Pirfenidone (300 mg/kg/day) for 4 wk. Pirfenidone significantly attenuates the score when administered in Bleomycin (BLM)-treated mice (P<0.0001). Moreover, collagen content is quantified in the lungs to evaluate the anti-fibrotic effects of Pirfenidone. The collagen content in the lungs of BLM-treated mice is significantly increased compared with that in saline- or Pirfenidone-treated mice, and this increase is significantly attenuated by Pirfenidone administration on day 28 after BLM treatment (P=0.0012) |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 5.3990 mL | 26.9949 mL | 53.9898 mL | 107.9797 mL |
| 5mM | 1.0798 mL | 5.3990 mL | 10.7980 mL | 21.5959 mL |
| 10mM | 0.5399 mL | 2.6995 mL | 5.3990 mL | 10.7980 mL |
| 20mM | 0.2699 mL | 1.3497 mL | 2.6995 mL | 5.3990 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.