Pioglitazone HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5g | $450 | Check With Us |
| 10g | $700 | Check With Us |
| 20g | $1050 | Check With Us |
: Cat #: V0820 CAS #: 112529-15-4 Purity ≥ 98%
Description: Pioglitazone HCl (also known as Actos; U-72107A; AD-4833; AD4833, U-72107E), the hydrochloride salt of Pioglitazone which is approved and thiazolidinedione-based anti-diabetic drug, is a selective PPARϒ agonist with hypoglycemic activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 392.9 |
|---|---|
| Molecular Formula | C19H20N2O3S.HCl |
| CAS No. | 112529-15-4 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 79 mg/mL (201.1 mM)r |
| Water:<1 mg/mLr | |
| Ethanol: 4 mg/mL (10.2 mM) | |
| SMILES Code | CCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3.Cl |
| Synonyms | AD-4833, U-72107E; Pioglitazone Hydrochloride; Pioglitazone HCl; Actos; U-72107A; AD-4833; pioglitazone; pioglitazone hydrochloride; U 72107A; U72,107A; U-72107A; AD 4833; |
| Protocol | In Vitro | AGEs-induced beta cell necrosis is completely abrogated by adding Pioglitazone to the AGEs culture medium. Furthermore Pioglitazone completely prevented any AGEs-induced increment in caspase-3 activation, thereby restoring caspase-3 activity to the same levels as the control cells. As expected AG is able to counteract AGEs-induced impaired viability. |
|---|---|---|
| In Vivo | The serum-free fatty acid and triglyceride levels as well as adipocyte sizes in ob/ob and adipo-/- ob/ob mice are unchanged after 10 mg/kg Pioglitazone but are significantly reduced to a similar degree after 30 mg/kg Pioglitazone. Moreover, the expressions of TNFα and resistin in adipose tissues of ob/ob and adipo-/- ob/ob mice are unchanged after 10 mg/kg Pioglitazone but are decreased after 30 mg/kg Pioglitazone. Thus, Pioglitazone-induced amelioration of insulin resistance and diabetes may occur adiponectin dependently in the liver and adiponectin independently in skeletal muscle. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5452 mL | 12.7259 mL | 25.4518 mL | 50.9035 mL |
| 5mM | 0.5090 mL | 2.5452 mL | 5.0904 mL | 10.1807 mL |
| 10mM | 0.2545 mL | 1.2726 mL | 2.5452 mL | 5.0904 mL |
| 20mM | 0.1273 mL | 0.6363 mL | 1.2726 mL | 2.5452 mL |
| Quality Control Documentation |
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The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.