Pilocarpine HCl

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
2g	$200	Check With Us
5g	$380	Check With Us
10g	$570	Check With Us

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Cat #: V1206 CAS #: 54-71-7 Purity ≥ 98%

Description: Pilocarpine HCl (Pilocarpal; NSC-5746; Ocusert; Pilocar;Pilocar SMP; Salagen; NSC5746), the hydrochloride salt of pilocarpine, is a naturally occurring and nonselective muscarinic acetylcholine receptor agonist used to treat dry mouth caused by radiotherapy in patients with head and neck cancer and in patients with Sjogren's syndrome.

References: Matsuzaki K, et al. Daily voluntary exercise enhances pilocarpine-induced saliva secretion and aquaporin 1 expression in rat submandibular glands. FEBS Open Bio. 2017 Dec 7;8(1):85-93.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	244.72
Molecular Formula	C11H16N2O2.HCl
CAS No.	54-71-7
Storage	-20℃ for 3 years in powder formrr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 49 mg/mL (200.2 mM)rr
	Water: 49 mg/mL (200.2 mM)rr
	Ethanol: N/A
SMILES Code	CCC1C(COC1=O)CC2=CN=CN2C.Cl
Synonyms	NSC 5746 HCl; Pilocarpine Hydrochloride; Pilocarpal; Pilocar; (+)-Pilocarpine hydrochloride; NSC-5746 HCl; NSC5746 HCl; Pilocar SMP; Salagen; Pilocarpine Mononitrate, (3S-cis)-Isomer; Pilocarpine Nitrate; Pilocarpine, Monohydrochloride, (3S-cis)-Isomer; Ocusert;

Protocol	In Vivo	The Pilocarpine-induced saliva secretion of the control rats (CN) and exercised (EX) rats is examined. A significantly greater amount of saliva is induced by Pilocarpine in the EX rats than in the CN rats (P<0.01). Conversely, the Na+ concentration in the saliva of the EX rats is significantly lower than that of the CN rats (P<0.05)

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	4.0863 mL	20.4315 mL	40.8630 mL	81.7261 mL
5mM	0.8173 mL	4.0863 mL	8.1726 mL	16.3452 mL
10mM	0.4086 mL	2.0432 mL	4.0863 mL	8.1726 mL
20mM	0.2043 mL	1.0216 mL	2.0432 mL	4.0863 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.