PI4KIIIbeta-IN-9
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1400 | To Be Confirmed |
| 250mg | $2300 | To Be Confirmed |
| 500mg | $3450 | To Be Confirmed |
: Cat #: V4965 CAS #: 1429624-84-9 Purity ≥ 98%
Description: PI4KIIIβ-IN-9 (PI4KIIIbeta-IN-9) is a novel, potent and selective PI4KIIIβ (Type III phosphatidylinositol 4-kinase) inhibitor with an IC50 of 7 nM with >1000-fold over class I and class III PI3Ks.
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| Molecular Weight (MW) | 487.59 |
|---|---|
| Molecular Formula | C₂₃H₂₅N₃O₅S₂ |
| CAS No. | 1429624-84-9 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | CC(N=C1NC(C2CCCC2)=O)=C(S1)C3=CC=C(C(S(=O)(NC4=CC=C(O)C=C4)=O)=C3)OC |
| Synonyms | PI4KIIIβ-IN-9; PI4KIIIbeta-IN-9; PI4KIIIβ-IN9; PI4KIIIbeta-IN9; PI4KIIIβ-IN 9; PI4KIIIbeta-IN 9; |
| Protocol | In Vitro | PI4KIIIbeta-IN-9 (Compound 9) shows weak inhibition of PI3KC2γ (IC50 ~1 µM), PI3Kα (~2 µM), and PI4KIIIα (~2.6 µM) and <50% inhibition at concentrations up to 20 µM for PI4K2α, PI4K2β, and PI3Kβ. PI4KIIIbeta-IN-9 (Compound 9) forms a crescent shape that conforms to the active site of PI4KIIIβ. This molecule makes extensive contacts with PI4KIIIβ. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0509 mL | 10.2545 mL | 20.5090 mL | 41.0181 mL |
| 5mM | 0.4102 mL | 2.0509 mL | 4.1018 mL | 8.2036 mL |
| 10mM | 0.2051 mL | 1.0255 mL | 2.0509 mL | 4.1018 mL |
| 20mM | 0.1025 mL | 0.5127 mL | 1.0255 mL | 2.0509 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.