PI4KIIIbeta-IN-10
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1400 | To Be Confirmed |
| 250mg | $2300 | To Be Confirmed |
| 500mg | $3450 | To Be Confirmed |
: Cat #: V4967 CAS #: 1881233-39-1 Purity ≥ 98%
Description: PI4KIIIβ-IN-10 (PI4KIIIbeta-IN-10) is a novel, potent and selective PI4KIIIβ (Type III phosphatidylinositol 4-kinase) inhibitor with an IC50 of 3.6 nM with >1000-fold over class I and class III PI3Ks.
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| Molecular Weight (MW) | 475.58 |
|---|---|
| Molecular Formula | C₂₂H₂₅N₃O₅S₂ |
| CAS No. | 1881233-39-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | COC1=CC=C(C2=C(C)N=C(NC(C(C)(C)C)=O)S2)C=C1S(NC3=CC=C(O)C=C3)(=O)=O |
| Synonyms | PI4KIIIβ-IN-10; PI4KIIIβ-IN10; PI4KIIIbeta-IN10; PI4KIIIbeta-IN-10; PI4KIIIβ-IN 10; PI4KIIIbeta-IN 10; |
| Protocol | In Vitro | PI4KIIIbeta-IN-10 (Compound 10) is a potent PI4KIIIβ inhibitor with very minor off-target inhibition of PI4KIIIβ related lipid kinases. PI4KIIIbeta-IN-10 shows weak inhibition of PI3KC2γ (IC50 ~1 µM), PI3Kα (~10 µM), and PI4KIIIα (~3 µM), and <20% inhibition at concentrations up to 20 µM for PI4K2α, PI4K2β, and PI3Kβ. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1027 mL | 10.5135 mL | 21.0270 mL | 42.0539 mL |
| 5mM | 0.4205 mL | 2.1027 mL | 4.2054 mL | 8.4108 mL |
| 10mM | 0.2103 mL | 1.0513 mL | 2.1027 mL | 4.2054 mL |
| 20mM | 0.1051 mL | 0.5257 mL | 1.0513 mL | 2.1027 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.