PHA-767491 HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $450 | Check With Us |
| 500mg | $750 | Check With Us |
| 1g | $1125 | Check With Us |
: Cat #: V2832 CAS #: 942425-68-5 Purity ≥ 98%
Description: PHA-767491 HCl (formerly known as CAY10572 HCl) is a novel potent ATP-competitive and dual CDC7/CDK9 inhibitor with IC50 of 10 nM and 34 nM in cell-free assays, respectively.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 249.7 |
|---|---|
| Molecular Formula | C12H11N3O.HCl |
| CAS No. | 942425-68-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 24 mg/mL (96.11 mM)r |
| Water: <1mg/mLr | |
| Ethanol: <1mg/mL | |
| Solubility In Vivo | O=C1C2=C(NC(C3=CC=NC=C3)=C2)CCN1.[H]Cl |
| Synonyms | CAY10572 HCl;CAY-10572 HCl; CAY 10572 HCl; PHA767491 HCl; PHA-767491 HCl; PHA 767491 HCl |
| Protocol | In Vitro | PHA-767491 hydrochloride conjugated to 5-FU exhibits greater cytotoxicity and induces significant apoptosis, as evidenced by significant increases in caspase-3 activation and poly(ADP-ribose) polymerase fragmentation in HCC cells. PHA-767491 hydrochloride directly counteracts 5-FU-induced Chk1 phosphorylation and reduces the expression of the anti-apoptotic protein myeloid leukemia cell 1ine |
|---|---|---|
| In Vivo | PHA-767491 hydrochloride reduces Chk1 phosphorylation and increases in situ apoptosis in tumor tissue sliced from nude mouse HCC xenografts |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.0048 mL | 20.0240 mL | 40.0481 mL | 80.0961 mL |
| 5mM | 0.8010 mL | 4.0048 mL | 8.0096 mL | 16.0192 mL |
| 10mM | 0.4005 mL | 2.0024 mL | 4.0048 mL | 8.0096 mL |
| 20mM | 0.2002 mL | 1.0012 mL | 2.0024 mL | 4.0048 mL |
The molarity calculator equation
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
%DMSO
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%ddH2O
Calculation Results:
Working concentration:
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Method for preparing DMSO master liquid:
mg
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.