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PF-4778574

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PF-4778574
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Cat #: V4444 CAS #: 1219633-99-4 Purity ≥ 98%

Description: PF-4778574 is a novel and potent positive allosteric modulation (PAM) of AMPA receptor with EC50 of 45 to 919 nM in differenct cells. Working memory impairments are a core aspect of schizophrenia, yet current medicines do not address such cognitive dysfunction. Positive modulation of AMPA receptors with LY451646 (0.1-1.0mg/kg, SC) and structurally distinct PF-4778574 (0.01mg/kg, SC) robustly ameliorates ketamine-induced working memory impairments without altering behavioral effects of acute ketamine we consider related to positive- and negative-like symptoms. These results support AMPA receptor potentiators as a potential adjunctive treatment for cognitive impairment associated with schizophrenia (CIAS).

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CAS No.1219633-99-4
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Quality Control Documentation
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The dilution calculator equation
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
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Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.