PF-4618433 | CAS 1166393-85-6

PF-4618433

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
100mg	$1950	Check With Us
200mg	$2925	Check With Us
500mg	$4935	Check With Us

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Cat #: V8608 CAS #: 1166393-85-6 Purity ≥ 98%

Description: PF-4618433 is a novel, potent and selective inhibitor of proline-rich tyrosine kinase 2 (PYK2) and focal adhesion kinase (FAK), showing improved PYK2 potency, reduced p38 activity, and superior overall selectivity relative to the prototype BIRB796.

References: Seungil H, et, al. Structural Characterization of Proline-Rich Tyrosine Kinase 2 (PYK2) Reveals a Unique (DFG-out) Conformation and Enables Inhibitor Design. J Biol Chem. 2009 May 8; 284(19): 13193-201.

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Quality Control Documentation

Molecular Weight (MW)	445.52
Molecular Formula	C24H27N7O2
CAS No.	1166393-85-6
SMILES Code	O=C(NC1=NNC(COC2=CC=CN=C2)=C1)NC3=CC(C(C)(C)C)=NN3C4=CC=C(C)C=C4
Synonyms	PF-4618433; PF4618433; PF 4618433;

Protocol	In Vitro	PF-4618433 (0.1-1.0 μM; 7 days) promotes osteogenesis of hMSC cultures. PF-4618433 increases in both alkaline phosphatase (ALP) activity and mineralization in a dependent manner.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.2446 mL	11.2228 mL	22.4457 mL	44.8914 mL
5mM	0.4489 mL	2.2446 mL	4.4891 mL	8.9783 mL
10mM	0.2245 mL	1.1223 mL	2.2446 mL	4.4891 mL
20mM	0.1122 mL	0.5611 mL	1.1223 mL	2.2446 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.